SAMethylate Plus™ supplies a stable source of SAMe with important synergists and building blocks, including vitamins B6 and B12, folate, L-methionine, choline bitartrate, trimethylglycine, SOD and catalase. SAMe is found in every living human cell and is the principal methyl group donor in a great many reactions in the body. It has the ability to cross the blood-brain barrier where it impacts the synthesis and activation of various brain chemicals, including neurotransmitters.